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Study ID Status Title Patient Level Data
105517/012 Completed A study to assess the acute effects of the co-administration of a single dose of 25mg carvedilol (SK&F 105517) on the plasma and urinary pharmacokinetics of digoxin after administration of a single intravenous dose of 0.5mg digoxin in normal man.
105517/013 Completed A study to assess the acute effects of a standard meal on the pharmacokinetics of carvedilol, after administration of a single oral dose of 25mg carvedilol in normal man.
105517/017 Completed A study to investigate the pharmacokinetics of carvedilol enantiomers and the metabolites of carvedilol in poor and extensive metabolizers of debrisoquin.
105517/021 Completed A multicenter, double-blind, placebo-controlled comparison of Carvedilol (SK&F) 6.25 mg, 12.5 mg, and 25.0 mg administered twice daily in patients with mild and moderate hypertension.
105517/022 Completed A multicenter, double-blind, placebo-controlled comparison of carvedilol (SK&F 105517) 6.25mg, 12.5mg, 25mg, and 50mg administered once daily in patients with mild to moderate hypertension.
105517/028 Completed Placebo controlled assessment of carvedilol (SK&F 105517) and labetalol in black patients with mild to moderate hypertension.
105517/030 Completed A crossover study to compare the effect of carvedilol (SK&F 105517) and atenolol administered orally on renal hemodynamics in patients with mild to moderate essential hypertension.
105517/031 Completed A study to investigate the effect of renal insufficiency on the pharmacokinetics of carvedilol and the metabolites of carvedilol after single and multiple dose administration in patients with hypertension.
105517/092 Completed A multicenter, double-blind, placebo-controlled, randomized assessment of carvedilol (SK&F 105517) administered once (UID) or twice (BID) daily to patients with mild to moderate hypertension.
105517/093 Completed A multicenter, double-blind, placebo-controlled, randomized assessment of carvedilol (SK&F 105517) in patients whose blood pressure is uncontrolled on hydrochlorothiazide (HCTZ).
105517/095 Completed Carvedilol (SK&F 105517) versus atenolol and placebo in patients with mild to moderate essential hypertension.
105517/099 Completed A multicenter, double-blind, crossover study of three doses of carvedilol compared to placebo in patients with exertional angina.
105517/100 Completed A multicenter, double-blind, crossover study of carvedilol compared to placebo in patients with exertional angina.
105517/121 Completed Carvedilol – captopril interaction study.
105517/123 Completed Carvedilol-nifedipine S.R. interaction study.
105517/124 Completed Comparison of carvedilol to atenolol in the treatment of mild to moderate essential hypertension.
105517/126 Completed Comparison of carvedilol to acebutolol in the treatment of mild to moderate benign essential hypertension.
105517/130 Completed A comparison of the safety and efficacy of carvedilol with that of nifedipine s.r. in patients with mild to moderate benign essential hypertension.
105517/132 Completed A multicentre study of efficacy and safety of carvedilol in the elderly.
105517/133 Completed A double-blind, placebo controlled study of the acute effect of carvedilol and atenolol in patients uncontrolled on bendrofluazide.
105517/136 Completed A comparison of carvedilol with hydrochlorothiazide in the treatment of mild to moderate benign essential hypertension.
105517/140 Completed Comparison of carvedilol to captopril in the treatment of mild to moderate hypertension.
105517/154 Completed The effect of oral carvedilol 6.25mg, 12.5mg, 25mg and 50mg on exercise-induced tachycardia and blood pressure in healthy volunteers.
105517/155 Completed Determination of alpha and beta blockade thresholds for carvedilol in comparison to 400mg labetalol in healthy volunteers.
105517/162 Completed A randomised, double-blind, placebo-controlled, 21-day repeat dose parallel group study to assess the irritancy of intranasal administration of BRL 4910F mupirocin 5% nasal spray in healthy volunteers.

 

 

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GSK-sponsored clinical studies are those for which GSK is ultimately responsible for all aspects of the study even if some or all of these activities are transferred to another party.
GSK-sponsored clinical trials are those for which GSK is ultimately responsible for all aspects of the study even if some or all of these activities are transferred to another party.

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